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Molecules activism could be viewed as the promotion of uncommon knowledge of commonplace things. The aspirin, the parsley, citrus fruits, all of which are commonplace things, readily in view and at hand. They all have little known properties which are highly valuable, although perhaps not in the shallow sense of monetary value. Common nuts, roots, and berries, which are sometimes valued little above the dirt that they sprout from, have unknown riches inside of them, not necessarily monetary wealth, but richness of health and strength. Such power is clearly not beyond our grasp, but it is merely unknown to us. We must establish such knowledge.Table salt is a much derided molecule, but it has been indispensible for its ability to preserve food, a little known property perhaps. The economic impact may be small and ambiguous, but it has arguably saved countless of the lives of our very forebearers. That is wealth that transcends money. Similar things could be said about other commonplace minerals and chemicals. such as; bleach, lime, and even oxygen, all of which have many important uses beyond the commonplace ones, and properties beyond those which are commonly known.Similar things could also be said of many ordinary spices; cinnamon, dill seeds, fennel, thyme, and common vegetables, such as tomatoes, and olives, as well as fruits, such as grapes. Many of these have preservative properties, but also they preserve life itself or increase our intellectual faculties, a vast and extraordinary richness indeed, beside which money is worth very little!Some will brush this argument aside saying that everything I have referred to costs money, and sufficient money will get you any of it. Although this is a commonplace sentiment, it is also widely recognized as a foolish one. Moreover, such arguments are made by people who would like to diminuate the value of our very lives, which is rightly a subject of much outrage. I say that money cannot possibly be compared in value to things like life, intelligence, and posterity. It is clear that there are riches unbeknownst to us at our very fingertips, and ever before our eyes. It also becomes obvious that the withholding of such knowledge is akin to a crime, and there are those of us in the movement who believe that the release of such knowledge should be MANDATORY. At least, those of us who are engaged in molecules activism will be doing our part to make such knowledge public, by the establishment of prior art, by publishing such knowledge, and by affixing it to the public common. Examples are many and growing, and they include this blog and the Molecules site. We will be generating more and more. Regards,
proclus
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Now that I have been high dosing flavonoids for a few weeks, I think that it may be time for another change. My stomach acid and digestion have apparently returned to what they were before I started, and I definitely still need my proton pump blocker. I have a hypothesis about this, which is difficult to confirm. It is known that NSAID drugs like aspirin reduce chloride conductance of the CFTR channel. This is due to the reduction of prostaglandins, which in turn are not present in sufficient quantity to produce cAMP and activate the channel. Aspirin users may initially have a reduction of stomach acid due to this fact, but it is well known that the stomach may become irritated and even ulcerated in due course. One reason for this lies in the fact that NSAIDS reduce CFTR gene expression, probably due to reduced genetic activation via prostaglandin receptors, known as PPAR's. With the prostaglandin receptors under-stimulated, due to the presence of the NSAID, insufficient CFTR is made by the cell. This leads to the now famous erosion of the mucosal lining of the stomach. This much is known.Hypothetically, it is likely that high doses of flavonoids, and other polyphenols such as resveratrol, will produce the same effect as the aspirin and other NSAIDS, because of similar inhibition of prostaglandin synthesis. Stimulation of cAMP production or CFTR activation would be insufficient to correct this protracted problem, because there would simply be not enough CFTR for sufficient mucous production to protect the lining of the stomach. As I have previously noted, my eyes are also still just a little dry, so that I have two different phenomena to cross check the effect of an aspirin hiatus. It may be one of those cases of too much of a good thing, or in other words; the combination of high flavonoids and aspirin, like the anti-histamine, is simply too strong. It should take at least several days for CFTR expression to recover and I hope to have more tears and reduced stomach complaints again in a week or two. Maybe I can get off the Nexium after all. It will likely be no surprise to other users of proton pump blockers, that I have a third metric as well, that queasy acid alkaseltzer headache and nauseous feeling, which I expect to go as well. Thankfully, this problem has also been mild in its manifestation. It is best to take care of these things before they become a serious problem. Wish me luck.If this hypothesis is true, then it is another case of the marvelous property of polyphenols to double up on their effects. For example, they inhibit COX and reduce COX expression. Likewise, they may block both CFTR channel activity and expression as well. It would be a profound effect and observation, because these type of double effects explain the refractory nature of CR-related regimens. As it has been noted, one continues to have the benefits of the regimen for at least several days after stopping. Cells have switches that are difficult to toggle back to their previous position, as it were, once they have been flipped. In this case, it is a forgiving regimen.Having said that, it should be noted that aspirin hiatus may be dangerous for people who have been prescribed aspirin by their doctor. As the coxib fiasco has demonstrated, too much of a good thing can be catastrophic, so that people who are vulnerable to these types of problems should exercise caution with flavonoid regimens as well, especially in the high dose range. Regards,
proclus
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I have added some refinements to my citrus pudding recipe, so that it is now a tastey classic pudding, which can be used as a pie stuffer, or even baked into a pleasant loaf. It includes my trademark 1/2 cup parsley.1/2 cup parsley flakes
1 medium to large citrus fruit
1 heaping teaspoon flax powder or nopalina
1 teaspoon cinnamon
1/2 teaspoon flax or olive oil
1/2 teaspoon fresh ground pepper.
2 tablespoons berry juice concentrate
1 large heaping tablespoonful of plain yogurt
1 large heaping tablespoonful peanut butter, or a small handful of nuts
1 bilberry teabag
1 Pau D'arco teabagMash ingredients together until well mixed. For pudding, microwave for 5.5 minutes on high. For bread, cook longer. Try mashing in some fresh fruit too, such as 1/2 cup of black grapes. Add a teaspoon of agave nectar, if you want it sweeter, but the mild tart flavor is pleasant and important for quenching the black pepper, which is a crucial part of the nutrient absorption regimen. This is definitely a citrus pudding, so don't substitute out the citrus.I really enjoy getting my citrus and parsley this way on the weekends and snow days. Hope that you do too! Regards,
proclus
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Parsley Seafood Nachos:1/2 cup of parsley flakes
1 large heaping tablespoonful of base sauce
1 large heaping tablespoonful of red salmon
1 ounce grated halbenero jack cheese
1/2 teaspoon of fresh ground pepper
1/2 teaspoon of ground red pepper, hot pepper sauce, or relishoptional:
1 large heaping tablespoonful of guacamole Use the base sauce from the chutney recipe. The onion in the base sauce is important. Mash the ingredients together until well mixed. The guacamole adds much to the flavor and a nice consistency, but it also has alot of calories. I wouldn't use it every time. Spread the result over corn chips and microwave on high for 1 minute. Alternatively, it can be served cold as a vegetable dip. Add a little lemon juice if you like. The parsley provides the bulk, so that this is a fairly low calorie recipe. It has alot of flavor, so remember to go easy on the chips! A little cheese and salmon goes a long way with this recipe. Regards,
proclus
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Osteoporosis and osteopenia were a topic of conversation in my department at Hopkins today, and as I listened to the discussion, it occurred to me that flavonoids like parsley apigenin might help to prevent adverse bone loss. It did not take much digging to find out that this is indeed the case, and there is even evidence that flavonoids may reverse bone loss. A quick search turned up this surprising statement from 2004. Flavonoids are micronutrients widely present in food of plant origin. They have been attributed pharmacological properties such as anticancer and prevention of age-related pathologies. It has been recently hypothesized that flavonoids increase bone mass and prevent osteoporosis.
Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF?B and AP-1
It also occurred to me that the real problem is not the normal osteoclast cells, which are required for the repair and day-to-day maintenance of bone. The problem of bone loss more likely results from abnormal osteoclast cells, which have mutated in similar ways as cancer cells. Moreover, these cells exhibit an important property of cancer cells: they are highly invasive. It is not difficult to imagine that flavonoid molecules, like parsley apigenin, would attenuate this undesired and abnormal invasiveness of osteoclasts gone bad. High dose apigenin has been demonstrated to kill several types of abnormal cells. Killing abnormal osteoclasts may reverse bone loss. Most importantly, the levels of flavonoid that are required to achieve some of these desirable effects are easily attainable using the methods described in this blog. In fact, the consumption of quercetin containing fruits has been demonstrated to reduce bone loss, and our methods increase the absorption of quercetin. Quercetin has been shown to have exceptional properties in the fight against bone loss, and parsley apigenin has been demonstrated to share in many of these same properties. Regards,
proclus
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I thought people who have been following the blog might like to read the Apigenin page at the Molecules site.Apigenin is probably the most inexpensive and widely available flavonoid, because it is present in more than 1:10 gram for gram quantities common parsley flakes in the form of apin. Apigenin is the resveratrol-like...The molecule of the day is: Apigenin
Regards,
proclus
http://www.gnu-darwin.org/
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 Hope that you enjoy this bit of verse. Be sure and pass the hugs around! I love you!, some verse by Michael L. Love Love, I am in a love lockdown.
It's love hate.
I say love you, not boy love.
I am fated to love you.
I want to say I love her.
I want to be your love guru, bad love.
Don't hate that I love you.
Don't say that I love money.
I want to play a lady gaga love game to you,
and say love sayings to you.
I will send you a love sms,
so that you will know that it is pure love.
I want to be in your love horoscope.
You have me in a love lock down.
It's not guy love.
It's not dvd love.
I want your love today.
Let's ride the rock of love bus.
It's not love and hate.
Be my computer love.
I love money 2.
Be in my love horoscopes.
We will be famous love,
and a love saying,
and cute love quotes,
love etc.
I'm in a love lock down.
It's skinny love.
It's your birthday love.
We will write the love definition,
and famous love quotes,
and sayings. It's not love vs money,
or sad love quotes.
We should be the definition of love,
and famous love quotes.
You are my rock of love.
I love saying I love you,
but it is unrequited love,
bon iver skinny love,
e cards love.
We were love 2007,
and love inc,
and love shayari.
It was funny love quotes,
the dream of love vs money.
You are on my bratz love meter.
This is a real chance at love,
ashley rock of love,
and famous love poems.
I mean inspirational love,
the love letters of great men,
not love dvds,
or love ecards,
or love my flash.
We had sayings about love,
taya rock of love.
Write love poems for her,
and love sonnets.
It's valentines day love.
We need a free love calculator,
and a real chance of love girls.
To love and die,
for love 21,
is a free love test. Write love poems for the one you love,
and you will need a true love calculator,
not an online love calculator,
to calculate your love. Get me to the love calculator. by Michael L. Love Regards,
proclus
http://www.gnu-darwin.org/
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