Wednesday, May 25, 2011

Filibuster Patriot Act Extension!

It appears that there are senators who are filibustering the Patriot Act Extension. Congrats to them, and we need more like them.


Tuesday, May 24, 2011

: #Anonymous fights Internet censorship; attacks US Chamber of Commerce

via Examiner National Edition Articles by Michael Stone, National Anonymous Examiner on 5/24/11

Monday the Internet hacktivist collective known as Anonymous launched a DDoS attack against the U.S. Chamber of Commerce in protest of the Protect IP act, legislation that some fear would impose a...

proclus : Michael L. Love: addressing backlash pain

proclus : Michael L. Love: addressing backlash pain


Michael L. Love: addressing backlash pain


There is an interesting phenomenon where pain killers might not work well under conditions I call prostaglandin crash: prostaglandins are already too low for Cox inhibitors such as aspirin, ibuprofen to have any effect.  This situation could relate to diabetic neuopathy and other types of neuropathy.  It may also relate to the unusual aches and pains that are sometimes experienced by people using calorie restriction (CR) related regimens like resveratrol or the parsley plan described elsewhere in this blog.  In both cases, prostaglandins may be unusually low, but for unrelated reasons, so that some pain treatments might not work. 

Prostaglandin crash is related, and may be the cause of another type of pain, which I call backlash pain.  You might have experienced this when using cough syrup.  Why does dextromethorphan (dxm) analgesia sometimes seem to make the pain or illness worse the next day?  This can also happen with morphine derivatives, and it is certainly related to their addictive potential.

Repressed function sometimes has a strong backlash.  For example, if a glutamate channel antagonist represses calcium release, then the calcium stores may continue to fill, so that there is a stronger activation after the antagonist wears off.  It is not difficult to imagine other types of repression/backlash events, and methamphetamine dependence is likely resulting from something similar as well, leading to dopamine depletion.

There are several possible strategies for reducing pain backlash.  In the case of the calcium stores, IP3 channel inhibition of some sort could prevent the backlash, as well as calcium pump inhibition.  Forskolin is obviously one such agent, which deactivates the IP3 channels.  It should be noted that forskolin also activates the voltage gated calcium channels.  If the calcium blockade results in too much potential, then these channels will open to rectify the situation, as it were, with a calcium transient.  One imagines that forskolin based regimens will not result in the elimination of pain, but rather its attenuation, and a reduction in backlash as well.  This has been consistent with my experience using the forskolin extract from NSI, which is one reason why I am recommending it as an adjunct to CR-related and parsley apigenin regimens.

Personally, there are a number of possible reasons why I am not experiencing pain backlash, and forskolin is likely one.  Another is the time-release formulation of dxm, and finally P450 inhibition by flavonoids, notably apigeinin, which keeps dxm in the system.

So we see that time release calcium channel antagonists is another possible strategy.  Anyone who has used valproate knows what I am talking about.  Another strategy is to identify other sources of calcium influx and repress them as well.  ATP receptor channel leaps to mind, and Blue #1 is apparently an effective agent for that.  In this case, it is extra-cellular calcium influx, like certain of the non-metabotropic glutamate receptors, which form channels.

Calcium influx is not the only issue, and the kinase activation which results from phospholipase activation may also be a source of repression/backlash.

Without anti-inflammatories, repression/backlash can be expected to result in more inflammatory factors being released, via the phospholipase/Cox pathway.  This may be an additional source of backlash.  It should be noted that flavonoids like parsley apigenin and other polyphenols like resveratrol may be sufficitent to suppress a backlash in prostaglandin production, without resort to anti-inflammatories.

In conclusion, a combination of CR-related regimen, dxm, and forskolin should address many pain management problems in a way that prevents the morning-after effect of prostaglandin crash and backlash pain.  Such a regimen may also find application for addiction treatment and recovery.



The blog



  • Michael L. Love: parsley and autism
  • Michael L. Love: parsley brownie
  • Michael L. Love: aspirin hiatus
  • Michael L. Love: citrus pudding recipe
  • Michael L. Love: parsley recipe alert!
  • Michael L. Love: parsley and bone loss
  • Michael L. Love: I Love You!
  • Michael L. Love: parsley and allergies follow-up
  • Michael L. Love: parsley and allergies
  • Michael L. Love: parsley and triglycerides
  • Michael L. Love: Parsley odyssey continues
  • Michael L. Love: Community blog to rss extraction code
  • Michael L. Love: winter bicycling
  • Michael L. Love: more parsley info, anti-diarrhea and other matters
  • Michael L. Love: Parsley recipe
  • Michael L. Love: polyphenols and stable free radicals
  • Michael L. Love: some bio info, blog links, plus some molecules site news
  • Michael L. Love: USDA Database for the Flavonoid Content
  • Michael L. Love: recipe; flax oil, tyrosol lignans update
  • Michael L. Love: Linus Pauling
  • Follow Michael L. Love:
    on Google Buzz

    Monday, May 23, 2011

    FROM CYNTHIA MCKINNEY: Gaza-Bound Aid Ship Issues Ultimatum to Egypt

    Thanks for the excellent work going into this post and flotilla effort.


    via Anita Stewart's Posts - DIGNITY by Anita Stewart on 5/23/11

    Gaza-Bound Aid Ship Issues Ultimatum to Egypt: Egypt--Regime Change or Face Change?



    Below please find a message from the Malaysian aid ship headed to Gaza, the Rachel Corrie.  They are in a dire situation, having been blockaded in international waters by Israel and not allowed to enter Gaza waters. They are running out of water and food. What does Egypt's treatment of this aid ship tell us about Egypt: Regime change or face change? 


    * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *

    Message from The Spirit of Rachel Corrie: 


    At 11am (Egyptian time), a unanimous decision was made to issue an ultimatum to the Egyptian Port Authority.


    If by 1400 hrs (Egyptian time), we are not allowed to dock and discharge cargo, we shall take that as official refusal and we shall leave Egypt and sail to Gaza.


    Matthias Chang, Mission Leader 

    (KL contact number +60123977586)




    Silence is the deadliest weapon of mass destruction.

    Saturday, May 21, 2011

    Stop the AT&T takeover of T-Mobile

    Dear Friend,

    AT&T's $39 billion proposal to take over T-Mobile is bad news for consumers, and a perfect example of what our anti-trust laws are supposed to prevent.

    If it's corporate influence as usual at the Federal Communications Commission (FCC), you can bet AT&T will emerge the winner and cell phone users will lose big time.

    The FCC is the only federal agency with jurisdiction over the takeover that accepts public comments on the record. It's crucial that we use the FCC's official comment period to demonstrate just how much public opposition there is to this deal.

    I just filed an official comment with the FCC protesting this takeover. Click on the link below for more information and to take action Regards,

    Tuesday, May 17, 2011

    proclus : How to kill an errant mast cell - #fasting #allergies

    Check out this website I found at

    How to kill an errant mast cell - #fasting #allergies
    How to kill a cell that lost a critical phosphatase?

    Don't know. The best strategy is to avoid making such errant
    cells. One possibility is to use metabolic control, calorie restriction,
    to keep the cell from getting activated. This does not kill the bad cell, it
    merely prevents activation, a workaround, a band-aid. It is crucial to get adequate supplementation during calorie restriction, because it
    is almost impossible to get all the vitamins you need on a restricted

    consider the mast cell:
    The cell turns on, but lingers on past the point of utility. It might not turn off at all. As a
    result, the system receives too much histamine, an adverse
    reaction, though usually a minor one. This is also an excellent
    analogy for things happening throughout the immune response and whole
    body. It is a metric for an error in metabolic control, the band-aid.
    In due course, the adversely activated cell is likely to suffer further
    damage, and then it will succumb to metabolic control like a cancer
    cell succumbs to chemo. Thus, sustained CR-related regimens _may_
    reduce the population of damaged cells over time. Tough work.
    The CR-memetics, like flavonoids, are also tough work, because they
    are so likely to make you hungry.

    Fasting might be easier, as abstinance is often easier than self-control.
    Fasting also might work faster, as it were, and more reliably. The
    reason for this may not be immediately apparent. Consider that the
    malfunctioning cell is using too much energy, and it is slow to
    come out of that state, if at all. Fasting lowers the overall energy level
    below what CR-related regimens can do, so that it might be expected
    to kill even more of the errant cells that are using too much energy.

    The duration of the fast matters. Even a good long night's sleep
    might be expected to kill some errant cells. Harder cases will
    require more fasting, and more extended fasting. It might be
    reasonable to extend the fast all the way to the point where it
    begins to become unhealthful, in order to kill the errant cells that
    are most intransigent. In my estimation, this might take more than
    a month, depending on the starting weight. Be sure and keep
    an eye on your BMI, body mass index. For a shorter fast,
    drop the supplements on the last few days. The healthy cells may
    have reduced needs for supplementation under deep fasting conditions,
    but errant cells, may be needing the nutrients, and they will already
    be stressed by the extended fast. If results are encouraging, then
    repeat the fast after a period of recovery. Be sure and resume a
    healthful diet and supplementation regimen as part of your recovery
    plan. You will likely find this part irresistable ;-}.

    After two extended fasts, I have become more concerned about the
    possibilty of muscle loss during fasting, but with my new Bowflex,
    this is less of a worry. Any healthful strength training regimen will do.

    I intend to start a second round of fasting in the next couple of weeks,
    having completed a six week fast at the end of March. I have been
    enjoying my recovery period very much, but I am also anxious to give
    this a try, with a ~7 day supplementation cutoff at the end. I may be letting you know
    how it turns out, and how the addition of strength training to the fast
    worked out as well.


    Saturday, May 14, 2011

    Coffee nuts?

    Much has been made of the antioxident effect of coffee and its metabolic
    derivatives. Give such care in the analysis, one wonders why it is not
    more frequently observed that roasting likely annihilates the beneficial
    quality of the substance. Moreover, in addition to destroying most of
    the beneficial antioxident character of the coffee, roasting likely produces unhealthful and even genotoxic alkaloids. Given the large
    amounts of caffeine and reactive phenolics with their unsaturated side
    chains, it seems inevitable to me. Most importantly perhaps, the same
    argument can be made regarding the roasting of nuts. Send me to Mars. I need to swear off of Planters Nuts. No snickers on my face.


    Wednesday, May 11, 2011

    The WikiLeaks Grand Jury and the Still Escalating War on Whistleblowing

    via (title unknown) by jon on 5/11/11

    Glenn Greenwald

    The contrast between these two headlines from this morning tells a significant story: From The Guardian (click image to enlarge):

    read more

    Breaking News from ACS Medicinal Chemistry Letters

    unknownname.out Download this file forwards this message to you.

    Forward to a friend

    Breaking News from ACS Medicinal Chemistry Letters


    Potential Natural Protection Against Radiation
    Featured in Medical News Today, MedPage Today, Red Orbit and HealthJockey: May 5, 2011

    In the midst of ongoing concerns about radiation exposure from the Fukushima nuclear power plant in Japan, scientists are reporting that a substance similar to resveratrol - an antioxidant found in red wine, grapes and nuts - could protect against radiation sickness. The report appears in ACS Medicinal Chemistry Letters... Read more


    Read the Article: The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from γ-Irradiation-Induced Death by Kazunori Koide, Sami Osman, Amanda L. Garner, Fengling Song, Tracy Dixon, Joel S. Greenberger, and Michael W. Epperly

    ACS Medicinal Chemistry Letters — publishes brief communications on experimental or theoretical results of exceptional timeliness in all aspects of medicinal chemistry (pure and applied) and its extension into pharmacology.


    ACS Publications: High Quality. High Impact.

    Copyright © 2011 American Chemical Society, All rights reserved.

    You are receiving this message because you are an active author in the field or have expressed
    an interest in this journal with the e-mail address
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    Tuesday, May 10, 2011

    It appears that powers are unwilling to address global warming. I suggest an investment in drilling and mining in Antartica.

    It appears that powers are unwilling to address global warming. I suggest an investment in drilling and mining in Antartica.

    Free Private Manning

    via (title unknown) by jon on 5/10/11

    Saul Landau

    In April, the Army transferred Private Bradley Manning from solitary confinement at Quantico, Virginia to the federal prison at Leavenworth, Kansas. At Quantico, according to a Human Rights Watch report, the military had shackled Manning, stripped him naked, and isolated him. The government attributed this cruel treatment to their fears that Manning might commit suicide.

    read more

    Sunday, May 8, 2011

    Asthma, red-faced histamine release, itchy eyes, etc, could be an a dvance indicator of pulmonary hypertension. Think mast cells. Just sayin.

    unknownname.out Download this file

    Asthma, red-faced histamine release, itchy eyes, etc, could be an advance indicator of pulmonary hypertension. Think mast cells. Just sayin.

    Thursday, May 5, 2011

    Anonymous responds to Sony allegations

    via Examiner National Edition Articles by Andrew Galbraith, Video Game Industry Examiner on 5/5/11

    Yesterday, in a letter to Congress, Sony detailed the steps they were making to resolve the issues that have been plaguing them since the Playstation Network and subsequently the SOE online components were hacked to the tune of over 100...

    Wednesday, May 4, 2011

    proclus : Michael L. Love: Elimination diet experiments, Bowflex, food allergies, etc

    Check out this website I found at

    Read the post at Vitacost blogs.


    Bin Laden

    Friends -

    Osama Bin Laden is dead, but will the Patriot Act live on? The Patriot Act was enacted as a supposedly temporary measure in the wake of 9-11. With Bin Laden's passing, the era of the Patriot Act, of spying on Americans who aren't suspected of crimes, of heavy-handed abuse of our dearly held civil liberties, must come to an end.

    Click here to urge your lawmakers to fix the Patriot Act:

    The Patriot Act is up for renewal this month and a key debate is brewing: Our opponents will argue that his death is evidence that the post-9-11 spying regime was justified. We believe it means that it's time for the government to fix the Patriot Act and start protecting Americans' civil liberties.

    We need to act now to make sure we win this fight. Tens of thousands of Demand Progress members have already urged Congress to fix the Patriot Act. Will you ask Congress and the President to return us to the legal norms that existed before 9-11 and start respecting our civil liberties? Just click here:

    Thank you.

    Tuesday, May 3, 2011

    Top News: NSA Says ETs Real, Miss USA Molested by TSA, Bin Laden Photo Faked

    via Fred Burks's feed by Fred Burks, US Intelligence Examiner on 5/2/11

    Below are key excerpts of important articles on a Miss USA's tearful statement of being molested upon refusing a TSA airport scan, a press photo of a dead Osama bin Laden proved to be fake, Pentagon generals being...