Tuesday, May 17, 2011

proclus : How to kill an errant mast cell - #fasting #allergies

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How to kill an errant mast cell - #fasting #allergies
How to kill a cell that lost a critical phosphatase?

Don't know. The best strategy is to avoid making such errant
cells. One possibility is to use metabolic control, calorie restriction,
to keep the cell from getting activated. This does not kill the bad cell, it
merely prevents activation, a workaround, a band-aid. It is crucial to get adequate supplementation during calorie restriction, because it
is almost impossible to get all the vitamins you need on a restricted
diet.

consider the mast cell:
The cell turns on, but lingers on past the point of utility. It might not turn off at all. As a
result, the system receives too much histamine, an adverse
reaction, though usually a minor one. This is also an excellent
analogy for things happening throughout the immune response and whole
body. It is a metric for an error in metabolic control, the band-aid.
In due course, the adversely activated cell is likely to suffer further
damage, and then it will succumb to metabolic control like a cancer
cell succumbs to chemo. Thus, sustained CR-related regimens _may_
reduce the population of damaged cells over time. Tough work.
The CR-memetics, like flavonoids, are also tough work, because they
are so likely to make you hungry.

Fasting might be easier, as abstinance is often easier than self-control.
Fasting also might work faster, as it were, and more reliably. The
reason for this may not be immediately apparent. Consider that the
malfunctioning cell is using too much energy, and it is slow to
come out of that state, if at all. Fasting lowers the overall energy level
below what CR-related regimens can do, so that it might be expected
to kill even more of the errant cells that are using too much energy.

The duration of the fast matters. Even a good long night's sleep
might be expected to kill some errant cells. Harder cases will
require more fasting, and more extended fasting. It might be
reasonable to extend the fast all the way to the point where it
begins to become unhealthful, in order to kill the errant cells that
are most intransigent. In my estimation, this might take more than
a month, depending on the starting weight. Be sure and keep
an eye on your BMI, body mass index. For a shorter fast,
drop the supplements on the last few days. The healthy cells may
have reduced needs for supplementation under deep fasting conditions,
but errant cells, may be needing the nutrients, and they will already
be stressed by the extended fast. If results are encouraging, then
repeat the fast after a period of recovery. Be sure and resume a
healthful diet and supplementation regimen as part of your recovery
plan. You will likely find this part irresistable ;-}.

After two extended fasts, I have become more concerned about the
possibilty of muscle loss during fasting, but with my new Bowflex,
this is less of a worry. Any healthful strength training regimen will do.

I intend to start a second round of fasting in the next couple of weeks,
having completed a six week fast at the end of March. I have been
enjoying my recovery period very much, but I am also anxious to give
this a try, with a ~7 day supplementation cutoff at the end. I may be letting you know
how it turns out, and how the addition of strength training to the fast
worked out as well.

Regards,
proclus
http://www.gnu-darwin.org/

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