Michael L. Love: parsley and bone loss
Osteoporosis and osteopenia were a topic of conversation in my department at Hopkins today, and as I listened to the discussion, it occurred to me that flavonoids like parsley apigenin might help to prevent adverse bone loss. It did not take much digging to find out that this is indeed the case, and there is even evidence that flavonoids may reverse bone loss. A quick search turned up this surprising statement from 2004.
Flavonoids are micronutrients widely present in food of plant origin. They have been attributed pharmacological properties such as anticancer and prevention of age-related pathologies. It has been recently hypothesized that flavonoids increase bone mass and prevent osteoporosis.
Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF?B and AP-1
It also occurred to me that the real problem is not the normal osteoclast cells, which are required for the repair and day-to-day maintenance of bone. The problem of bone loss more likely results from abnormal osteoclast cells, which have mutated in similar ways as cancer cells. Moreover, these cells exhibit an important property of cancer cells: they are highly invasive. It is not difficult to imagine that flavonoid molecules, like parsley apigenin, would attenuate this undesired and abnormal invasiveness of osteoclasts gone bad. High dose apigenin has been demonstrated to kill several types of abnormal cells. Killing abnormal osteoclasts may reverse bone loss.
Most importantly, the levels of flavonoid that are required to achieve some of these desirable effects are easily attainable using the methods described in this blog. In fact, the consumption of quercetin containing fruits has been demonstrated to reduce bone loss, and our methods increase the absorption of quercetin. Quercetin has been shown to have exceptional properties in the fight against bone loss, and parsley apigenin has been demonstrated to share in many of these same properties.Share |
on Google BuzzPublished Wednesday, February 17, 2010 09:44 PM by proclus