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Now that my eyes have been sensitized to dryness for the very first time in my life, I think that I can describe something I would call parsley eyes. They are apparently a little dryer than what they normally would be, even without any anti-histamine. In fact, my eyes have returned to normal, though perhaps occasionally on the dry side of normal. On my bicycle this morning, it was clear that my wet winter nose had returned. The stye is gone, and I stopped the niacin a day or two ago. Of course, the dryness would be linked to the CFTR blockade from the parsley regimen, but it also appears that a normal dose of anti-histamine was far too much, when combined with the parsley. I think that a few doses of niacin helped the stye recovery immensely, and now I think I am in the normal range, better than I was before. This experience has taught me very much about the interplay between flavonoids and histamine. In the future, I may experiment with a very low dose of anti-histamine, which may be beneficial, if you can find one with high H1 receptor selectivity. Now that the dry eyes has been solved, I will be continuing with the parsley regimen for the foreseeable. There are just too many benefits from high dose polyphenol to give the parsley up, besides the fact that it is delicious. This would be a good time to reiterate concerns around the use of flavonoid and polyphenol supplements with respect to development; pregnancy, nursing, and little children. As I have previously pointed out these concerns, I would only wish to indicate this caveat. For example, some women are using parsley in an attempt to restore or regularize menstruation. I don't know if it is effective, but if so, then there could obviously be a danger of miscarriage during pregnancy or worse. Regards, proclus http://www.gnu-darwin.org/ |
Yesterday I realized that people with allergies might like to try the parsley regimen. I have definitely had dry eyes and nose as a result of using this much parsley, and I think I actually developed an eye stye because of it. Of course, this speaks to the histamine connection. I had been taking an anti-histamine for atopic cough and runny nose, which are allergy-like symptoms, and it appears that the parsley regimen has eliminated that problem. Because of the stye, I stopped the anti-histamine, so that I would have more tears, and I have started taking niacin again, which I intend to do until the stye is gone. Today I have tears in my eyes, so that it appears that the combination of parsley regimen and anti-histamine was too strong for me. This is still preliminary in my case, but it would be wonderful if people could use parsley to reduce their allergy symptoms, and reduce or eliminate their anti-histamine use as indicated. It is clear that many who suffer from allergies or related problems would like to give this a try in order to get some relief. Parsley apigenin has been demonstrated to reduce cell invasiveness, which is a big part of the allergy problem and cancer too. My atopic cough is far better after two weeks of this parsley regimen. Research relates atopic cough directly to immune system invasion in the trachea. Perhaps we can add this parsley regimen to the body of allergy information and remedies. Time will tell. More later. Regards,
proclus
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How might apigenin chloride channel blockade decrease serum triglycerides? In other words, could one reduce serum triglycerides by eating parsley? What follows is abit speculative, and I will admit that I have not yet researched the topic fully in the literature. More will follow. If you are comfortable with the fact the following may contain inaccurate extrapolations, the proceed. The first thing to observe is that a decrease in serum triglycerides would be a paradoxical effect. The channel blockade agents that are being considered here are also COX inhibitors and COX expression inhibitors, so that at low dose they can be expected to raise serum triglycerides, as observed. At high dose, the agents would tend to raise the hydrostatic pressure of the cell, by blocking one of the primary means of reducing that pressure, the CFTR chloride channels. The physical model indicates, that increased hydrostatic pressure may lead to increased inward vesicular transport, and reduce serum triglycerides. The mechanism is unknown to me at this time. Some things about the pathway and mechanism are known to me, for example, COX inhibitors would tend to raise serum triglycerides, because the product of the COX reaction, prostaglandins, binds to PPAR alpha and activates inward vesicular transport, probably by some genetic mechanism. It should be noted that prostaglandin production is the direct result of the activity of phospholipase, which provides the COX reagents. One could hypothesize that a cellular response to CFTR blockade combined with COX inhibition would be the release of agents which activate phospholipase activity, such as histamine and norepinephrine. By doing this, the cell would be attempting to make more COX reagents, so that the inward vesicular transport can be turned on, perhaps in order to avoid hydrostatic rupture. Hydrostatic rupture is probably an over-statement, and what we are discussing are more like tendencies, rather than requirements. One observation in support of this argument would be that cAMP-activated CFTR chloride permeabiltiy is able to overcome the blockade to varying degrees. The blockade is unlikely to be complete under cAMP-activated conditions. In fact, in cells which express cAMP coupled receptors, such as the beta-adenergic receptors, extra-cellular ligands to these receptors can be expected to alleviate hydrostatic pressure, without recourse to vesicular transport. Moreover, the cell likely has other means of releasing solutes to draw out water. For example, there is another important chloride channel, which may play a key role. More on that later. Two of the ligands which can activate both phospholipase and cAMP production are histamine and adenergics, such as epinephrine and norepinephrine, and cellular secretion of these products would be expected to help relieve hydrostatic pressure, by activating both CFTR, and inward vesicular transport, even during CFTR blockade which tends to be partial. This cellular response may take time to come to full fruition, perhaps days or weeks. It should be noted that alpha-1 and H1 activation leading to phospholipase activity is the very stress response that we are trying to avoid. Phospholipase activity is associated with many problems, being implicated in cancer for example, and one infers that phospholipase activators would have the same association. My experience is consistent with adenergic activation resulting from CFTR blockade, but I will need another week or so to eliminate some extraneous factors. Such activation would also be consistent with some of the puzzling and unexpectedly elevated blood pressure readings that I have had transiently in recent days. Are blockading levels of resveratrol or flavonoids beneficial in the overall sense? My parsley experience clearly rings a cautionary note, but the animal experiments are indicating that a higher dose is consistent with deeper CR memesis, and that it is more healthfully beneficial than a lower dose. Perhaps the explanation for this observation resides in the intestine, resulting from CFTR blockade, but it may also result from a greater increase in triglyceride transport, especially inward transport. I am anxiously awaiting my next blood triglyceride assay. I would also add that increasing water intake is recommended for the parsley regimen in order to compensate for the diminished mucous secretion, among other things. Regards, proclus http://www.gnu-darwin.org/ |
I don't know if I am the first person to eat a cup of parsley flakes every day. I doubt it, but there are not many reports. It is definitely a learning experience. For example, my eyes are a little dry, certainly due the CFTR inhibition by apigenin. It is only a little bothersome, and not severe. I have never had dry eyes in my life, and it is an interesting experience. I don't plan to resort to an eye wash. I may reduce my dose somewhat, but not yet, I am having too much fun.As noted below, this program easily puts gram levels of flavonoids into your body, and as a plus, you will enjoy the marvellous parsley flavor as never before. Due to the high flavonoid content, there is a possible increased likelihood of intestinal blockage with prolonged use, again because of the CFTR blockade. If you are like me, you will merely experience more regularity, but as noted before, those who might have intestinal problems, such as cryptitis, should probably not use this much parsley. It is remarkable how widespread the effects of CFTR blockade are in the body. My heartburn is much diminished since starting the parsley regimen, which would also be a consistent effect, since CFTR function is a key component of acid secretion in the stomach, as well as acid quenching in the duodenum. In fact, this is a key reason why cystic fibrosis patients require special diets, and enzyme supplementation. I would suspect that this is one reason why enzymes are so popular in the supplement community.Another thing that I am noticing is a prolonged and enhanced effect of dextromorphan. This is confirmational of the finding that apigenin, like several other flavoniods, inhibits a p450 enzyme that is involved in dextromorphan metabolism, among several other drugs. A reduced dose may be indicated, and I will be getting my scheduled liver and kidney tests promptly. My experience is that this enhanced effect is profound, and my coughing symptoms have improved vastly. It should be noted at this point that this much parsley is quite diuretic as well. These effects are not limited to parsley or apigenin, and there are quite a few polyphenols that are capable of producing a CFTR blockade, notably resveratrol. If you get very far above gram level dosing, you are also likely to experience similar effects with quercetin. The same is true for the p450 inhibition. I am learning more about the parsley plant. For example, the root and seeds have much more of the other interesting parsley molecule, apiol, also known as parsley extract, parsley oil, or parsley camphor. There is much to say about apiol, but I will only give it a cursory treatment. There is much information about this molecule elsewhere on the web. The apiol extract is an anciently known preparation with many uses, including regularization of menstruation and an abortitive property. It is also somewhat dangerous, and there are even reported fatalities from ingesting too much apiol. Perhaps some young women, eager to restore their menstruation, unfortunately abused this chemical in the camphor form.Apiol can have other unhealthful effects, and it has even been demonstrated to form DNA adducts, due to its extended reactive end-group. This is a commonplace problem associated with the 1-allyl side chain, which is found in many flavonoid producing plants. Unlike some other compounds, apiol forms weak adducts, which are apparently easily rectified in the cell, and there is much less apiol in the leaves, which is unlikely to present a problem.I would be interested in hearing if any women are experiencing regularization of menstruation while on this parsley regimen. The effect may be small to nil, due to the comparitively low apiol content of the parsley flakes.Well, this turned out to be rather exhuastive after all. Cheers! Regards,
proclus
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I have written a wee bit of code to make a custom rss feed from a Vitacost Community Blog. Anyone is free to use it as you like. Pass the result through rss2html.pl, and you get this... You can see an implementation on the Molecules site. If you want help with an implementation, I'll take questions in the comments section. I may be making improvements according to suggestions, but I doubt it. Hope you enjoy the result. Cheers! Regards, proclus http://www.gnu-darwin.org/ |
I have been commuting by bicycle for most of the last 30 years. This is the season that I get the most comments from people, who sometimes wonder how I manage to ride in the winter weather. I am delighted to see more bicyclists on the streets of Baltimore this winter, which means that there are more people who are committed urban bicycling. I ride a folding, ultra-lite, and I have posted several new photos, including a picture of my bicycle. I don't own a car, and I work regular hours. It is about a 20-30 minute commute on my bicycle, and hilly, so that I get adequate exercise. I have daily incentive to do so, and wonder if I would get any exercise at all without this regimen. Winter riding is only a little harder than other seasons. If there is snow, one must be mindful of the piles of snow, which commonly narrow the road, and make passage more difficult in traffic. Different types of snow present different problems, and possibilities are about endless, but you get the hang of it in time. Keeping an eye out for the occasional patch of ice is the main precaution. There is no quicker way to fall down on the pavement than to try and ride a bicycle on icy pavement. It feels very hard that way, especially in winter. I started this regimen when I was 16 years old, because my girlfriend, Mary, lived about 5 miles away, and I did not own a car at the time. My parents demanded a strict curfew, and I always found myself racing home in order to beat the clock at the last minute. Later, I served a mission for the LDS church. Perhaps you have seen the young men in suits, riding bicycles in pairs. Maybe that was me. After my mission, I was committed to bicycle riding for health reasons, but also for the sake of the environment, and to save money. I live a far more comfortable lifestyle because I do not own a car, with its many expenses. I buy no gasoline, which makes good sense to me. Trust me, I am a lifer. With all of my bicycling experience, I can manage the additional winter precautions very well. I have nice warm riding gloves, which addresses the main problem really, cold hands. Urban riding in general presents additional challenges, such as broken glass, parallel storm drain gratings, railroad tracks, pot holes and other obstacles, and how to manage a small load of groceries or shopping items on the bicycle. Winter is just a little more to think about. It is good for the mind to think while under the stress of exercise, and these challenges give one plenty to think about, to say nothing about inconsiderate drivers. I am expecting research to show higher intelligence scores among life-long bicyclists. There are already hints in this direction. Think about it; no contribution to pollution, free and easy parking near the entrance, no tedious trips to the gas station or repair shop, with those expenses, and no car insurance. You also have the satisfaction of knowing that you are not contributing to problems of US foreign policy or to the green house effect. If that were not all, you are contributing immensely to your overall health and well being, and you will be admired by many as well for all of these reasons and more, perhaps your great legs. Sell your car. Ride a bicycle. Do it now. Regards,
proclus
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Diarrhea is a frequently problem for those who undertake supplementation and vegetarian-style regimens. On the other hand, what for some of us is a minor inconvenience or annoyance can become life-threatening in some parts of the world where there are complicating issues. It is a real problem, which is larger than some of us think, and the dehydration resulting from diarrhea may be dangerous for those who are using supplements as well. First advice is drink plenty of water if you are using supplements. It should be noted that water shock can be fatal in severe cases. As it happens, certain flavonoids have been documented to have a paradoxical anti-diarrhea property when taken in large doses. This is due to inhibition of the ATP-cAMP-dependent chloride channel (CFTR), and these flavonoids have been suggested as a remedy in cases where diarrhea might become dangerous. Parsley flavonoid shares in the ability to block this channel and slow digestion, so that water can be absorbed from the intestine. Fortunately, parsley is a widely available commodity, even in some of the poorest of countries. I am recommending that an anti-diarrhea emulsion could include enough parsley to help save lives. It has been demonstrated that such inexpensive preparations can do great good. It can be flavored with a little sweetener for small children. Diarrhea can take its toll, particularly on the young, hopefully this information will help to prevent the death of some little ones. Interestingly, the cystic fibrosis disease results from a defect in this same chloride channel. The wide range of symptoms indicate how widespread this channel is in the body, including the nasal passages and lungs. Those suffering from intestinal maladies, such as cryptitis, should consider avoiding such things as quercetin and parsley flakes. There is some evidence that we can find alternative flavonoid regimens for them, which do not inhibit the channel. I am including below a salient reference. Regards,
proclus
http://www.gnu-darwin.org/ Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia
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