Wednesday, May 25, 2011
Tuesday, May 24, 2011
Monday the Internet hacktivist collective known as Anonymous launched a DDoS attack against the U.S. Chamber of Commerce in protest of the Protect IP act, legislation that some fear would impose a...
|There is an interesting phenomenon where pain killers might not work well under conditions I call prostaglandin crash: prostaglandins are already too low for Cox inhibitors such as aspirin, ibuprofen to have any effect. This situation could relate to diabetic neuopathy and other types of neuropathy. It may also relate to the unusual aches and pains that are sometimes experienced by people using calorie restriction (CR) related regimens like resveratrol or the parsley plan described elsewhere in this blog. In both cases, prostaglandins may be unusually low, but for unrelated reasons, so that some pain treatments might not work. |
Prostaglandin crash is related, and may be the cause of another type of pain, which I call backlash pain. You might have experienced this when using cough syrup. Why does dextromethorphan (dxm) analgesia sometimes seem to make the pain or illness worse the next day? This can also happen with morphine derivatives, and it is certainly related to their addictive potential.
Repressed function sometimes has a strong backlash. For example, if a glutamate channel antagonist represses calcium release, then the calcium stores may continue to fill, so that there is a stronger activation after the antagonist wears off. It is not difficult to imagine other types of repression/backlash events, and methamphetamine dependence is likely resulting from something similar as well, leading to dopamine depletion.
There are several possible strategies for reducing pain backlash. In the case of the calcium stores, IP3 channel inhibition of some sort could prevent the backlash, as well as calcium pump inhibition. Forskolin is obviously one such agent, which deactivates the IP3 channels. It should be noted that forskolin also activates the voltage gated calcium channels. If the calcium blockade results in too much potential, then these channels will open to rectify the situation, as it were, with a calcium transient. One imagines that forskolin based regimens will not result in the elimination of pain, but rather its attenuation, and a reduction in backlash as well. This has been consistent with my experience using the forskolin extract from NSI, which is one reason why I am recommending it as an adjunct to CR-related and parsley apigenin regimens.
Personally, there are a number of possible reasons why I am not experiencing pain backlash, and forskolin is likely one. Another is the time-release formulation of dxm, and finally P450 inhibition by flavonoids, notably apigeinin, which keeps dxm in the system.
So we see that time release calcium channel antagonists is another possible strategy. Anyone who has used valproate knows what I am talking about. Another strategy is to identify other sources of calcium influx and repress them as well. ATP receptor channel leaps to mind, and Blue #1 is apparently an effective agent for that. In this case, it is extra-cellular calcium influx, like certain of the non-metabotropic glutamate receptors, which form channels.
Calcium influx is not the only issue, and the kinase activation which results from phospholipase activation may also be a source of repression/backlash.
Without anti-inflammatories, repression/backlash can be expected to result in more inflammatory factors being released, via the phospholipase/Cox pathway. This may be an additional source of backlash. It should be noted that flavonoids like parsley apigenin and other polyphenols like resveratrol may be sufficitent to suppress a backlash in prostaglandin production, without resort to anti-inflammatories.
In conclusion, a combination of CR-related regimen, dxm, and forskolin should address many pain management problems in a way that prevents the morning-after effect of prostaglandin crash and backlash pain. Such a regimen may also find application for addiction treatment and recovery.
on Google Buzz
Monday, May 23, 2011
Gaza-Bound Aid Ship Issues Ultimatum to Egypt: Egypt--Regime Change or Face Change?
Below please find a message from the Malaysian aid ship headed to Gaza, the Rachel Corrie. They are in a dire situation, having been blockaded in international waters by Israel and not allowed to enter Gaza waters. They are running out of water and food. What does Egypt's treatment of this aid ship tell us about Egypt: Regime change or face change?
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Message from The Spirit of Rachel Corrie:
At 11am (Egyptian time), a unanimous decision was made to issue an ultimatum to the Egyptian Port Authority.
If by 1400 hrs (Egyptian time), we are not allowed to dock and discharge cargo, we shall take that as official refusal and we shall leave Egypt and sail to Gaza.
Matthias Chang, Mission Leader
(KL contact number +60123977586)
Silence is the deadliest weapon of mass destruction.
Saturday, May 21, 2011
Tuesday, May 17, 2011
How to kill an errant mast cell - #fasting #allergies
How to kill a cell that lost a critical phosphatase?
Don't know. The best strategy is to avoid making such errant
cells. One possibility is to use metabolic control, calorie restriction,
to keep the cell from getting activated. This does not kill the bad cell, it
merely prevents activation, a workaround, a band-aid. It is crucial to get adequate supplementation during calorie restriction, because it
is almost impossible to get all the vitamins you need on a restricted
consider the mast cell:
The cell turns on, but lingers on past the point of utility. It might not turn off at all. As a
result, the system receives too much histamine, an adverse
reaction, though usually a minor one. This is also an excellent
analogy for things happening throughout the immune response and whole
body. It is a metric for an error in metabolic control, the band-aid.
In due course, the adversely activated cell is likely to suffer further
damage, and then it will succumb to metabolic control like a cancer
cell succumbs to chemo. Thus, sustained CR-related regimens _may_
reduce the population of damaged cells over time. Tough work.
The CR-memetics, like flavonoids, are also tough work, because they
are so likely to make you hungry.
Fasting might be easier, as abstinance is often easier than self-control.
Fasting also might work faster, as it were, and more reliably. The
reason for this may not be immediately apparent. Consider that the
malfunctioning cell is using too much energy, and it is slow to
come out of that state, if at all. Fasting lowers the overall energy level
below what CR-related regimens can do, so that it might be expected
to kill even more of the errant cells that are using too much energy.
The duration of the fast matters. Even a good long night's sleep
might be expected to kill some errant cells. Harder cases will
require more fasting, and more extended fasting. It might be
reasonable to extend the fast all the way to the point where it
begins to become unhealthful, in order to kill the errant cells that
are most intransigent. In my estimation, this might take more than
a month, depending on the starting weight. Be sure and keep
an eye on your BMI, body mass index. For a shorter fast,
drop the supplements on the last few days. The healthy cells may
have reduced needs for supplementation under deep fasting conditions,
but errant cells, may be needing the nutrients, and they will already
be stressed by the extended fast. If results are encouraging, then
repeat the fast after a period of recovery. Be sure and resume a
healthful diet and supplementation regimen as part of your recovery
plan. You will likely find this part irresistable ;-}.
After two extended fasts, I have become more concerned about the
possibilty of muscle loss during fasting, but with my new Bowflex,
this is less of a worry. Any healthful strength training regimen will do.
I intend to start a second round of fasting in the next couple of weeks,
having completed a six week fast at the end of March. I have been
enjoying my recovery period very much, but I am also anxious to give
this a try, with a ~7 day supplementation cutoff at the end. I may be letting you know
how it turns out, and how the addition of strength training to the fast
worked out as well.
Saturday, May 14, 2011
derivatives. Give such care in the analysis, one wonders why it is not
more frequently observed that roasting likely annihilates the beneficial
quality of the substance. Moreover, in addition to destroying most of
the beneficial antioxident character of the coffee, roasting likely produces unhealthful and even genotoxic alkaloids. Given the large
amounts of caffeine and reactive phenolics with their unsaturated side
chains, it seems inevitable to me. Most importantly perhaps, the same
argument can be made regarding the roasting of nuts. Send me to Mars. I need to swear off of Planters Nuts. No snickers on my face. Regards,
Wednesday, May 11, 2011
The contrast between these two headlines from this morning tells a significant story: From The Guardian (click image to enlarge):
email@example.com forwards this message to you.
Forward to a friend Breaking News from ACS Medicinal Chemistry Letters
Tuesday, May 10, 2011
It appears that powers are unwilling to address global warming. I suggest an investment in drilling and mining in Antartica.
In April, the Army transferred Private Bradley Manning from solitary confinement at Quantico, Virginia to the federal prison at Leavenworth, Kansas. At Quantico, according to a Human Rights Watch report, the military had shackled Manning, stripped him naked, and isolated him. The government attributed this cruel treatment to their fears that Manning might commit suicide.
Sunday, May 8, 2011
Asthma, red-faced histamine release, itchy eyes, etc, could be an a dvance indicator of pulmonary hypertension. Think mast cells. Just sayin.
Asthma, red-faced histamine release, itchy eyes, etc, could be an advance indicator of pulmonary hypertension. Think mast cells. Just sayin.
Thursday, May 5, 2011
Yesterday, in a letter to Congress, Sony detailed the steps they were making to resolve the issues that have been plaguing them since the Playstation Network and subsequently the SOE online components were hacked to the tune of over 100...
Wednesday, May 4, 2011
Read the post at Vitacost blogs.
Tuesday, May 3, 2011
Below are key excerpts of important articles on a Miss USA's tearful statement of being molested upon refusing a TSA airport scan, a press photo of a dead Osama bin Laden proved to be fake, Pentagon generals being...